A one-pot, multicomponent tandem synthesis of fused polycyclic pyrrolo[3,2-<i>c</i>]quinolinone/pyrrolizino[2,3-<i>c</i>]quinolinone hybrid heterocycles via environmentally benign solid state melt reaction

Abstract Structurally diverse fused polycyclic pyrrolo[3,2- c ]quinolinone/pyrrolizino[2,3- ]quinolinone hybrids were synthesized to get excellent yields via a tandem multi-component reaction sequence employing an environmentally benign solid state melt involving [3+2]-cycloaddition process followed by two consecutive annulation steps. Baylis–Hillman products, used as dipolarophiles, from various substituted aryl/heteroaryl aldehydes in the presence of DABCO and methyl acrylate, while 1,3-dipole component was derived situ indoline-2,3-dione acyclic/cyclic amino acid viz N -methylgylcine/ l -proline. The structure unusual products unambiguously assigned spectroscopic XRD analysis. arose through formation three new rings, five bonds, adjoining stereocenters with complete diastereomeric control.